for example:
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331831/
"Transwoman Elite Athletes: Their Extra Percentage Relative to Female Physiology"
Int J Environ Res Public Health. 2022 Aug; 19(15): 9103.
Published online 2022 Jul 26. doi: 10.3390/ijerph19159103
There is increasing debate as to whether transwoman athletes should be included in the elite female competition. Most elite sports are divided into male and female divisions because of the greater athletic performance displayed by males. Without the sex division, females would have little chance of winning because males are faster, stronger, and have greater endurance capacity. Male physiology underpins their better athletic performance including increased muscle mass and strength, stronger bones, different skeletal structure, better adapted cardiorespiratory systems, and early developmental effects on brain networks that wires males to be inherently more competitive and aggressive. Testosterone secreted before birth, postnatally, and then after puberty is the major factor that drives these physiological sex differences, and as adults, testosterone levels are ten to fifteen times higher in males than females. The non-overlapping ranges of testosterone between the sexes has led sports regulators, such as the International Olympic Committee, to use 10 nmol/L testosterone as a sole physiological parameter to divide the male and female sporting divisions. Using testosterone levels as a basis for separating female and male elite athletes is arguably flawed. Male physiology cannot be reformatted by estrogen therapy in transwoman athletes because testosterone has driven permanent effects through early life exposure. This descriptive critical review discusses the inherent male physiological advantages that lead to superior athletic performance and then addresses how estrogen therapy fails to create a female-like physiology in the male. Ultimately, the former male physiology of transwoman athletes provides them with a physiological advantage over the cis-female athlete.
[...]
Irreversible changes to male physiology.
Figure 1 shows the irreversible changes of testosterone conditioning throughout life. Testosterone masculinizes the brain in utero and during early life. Testosterone drives anatomical structure design specific to the male skeleton. Testosterone drives muscle mass, muscle fiber type, and muscle memory. Most of the effects driven by testosterone cannot be reversed with estradiol (or cross) hormone therapy.