the limitations

Posted on: May 30, 2025 at 13:41:03 CT

This study has several limitations. Variability in cannabis strains complicates standardization. Self-reported cannabis use may introduce recall bias; thus, participants were queried at multiple points: in the online survey, at the eligibility interview, and before each visit. Interpreting physiological end points like FMD, arterial stiffness, or blood pressure can be challenging due to variability, lifestyle factors (eg, stress, caffeine, secondhand smoke exposure), and the cross-sectional rather than longitudinal nature of the study. These potential confounding effects were minimized by strict inclusion and exclusion criteria and validation by measuring circulating cannabinoid and nicotine metabolites.

so this is one of those uncontrolled studies that use surveys to determine results. It does not look at parameters before and after.

And being 55 people with a lot of variability in the people make this extremely difficult to interpret at all.