Note
https://www.nature.com/articles/nm.3985
30 March 2020 Editors’ note, March 2020: We are aware that this article is being used as the basis for unverified theories that the novel coronavirus causing COVID-19 was engineered. There is no evidence that this is true; scientists believe that an animal is the most likely source of the coronavirus.
Authors were from multiple institutions:
Affiliations
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Vineet D Menachery, Boyd L Yount Jr, Kari Debbink, Lisa E Gralinski, Jessica A Plante, Rachel L Graham, Trevor Scobey, Eric F Donaldson & Ralph S Baric
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Kari Debbink & Ralph S Baric
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
Sudhakar Agnihothram
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Xing-Yi Ge & Zhengli-Li Shi
Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Scott H Randell
Cystic Fibrosis Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Scott H Randell
Institute for Research in Biomedicine, Bellinzona Institute of Microbiology, Zurich, Switzerland
Antonio Lanzavecchia
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Wayne A Marasco
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Wayne A Marasco
Contributions
V.D.M. designed, coordinated and performed experiments, completed analysis and wrote the manuscript. B.L.Y. designed the infectious clone and recovered chimeric viruses; S.A. completed neutralization assays; L.E.G. helped perform mouse experiments; T.S. and J.A.P. completed mouse experiments and plaque assays; X.-Y.G. performed pseudotyping experiments; K.D. generated structural figures and predictions; E.F.D. generated phylogenetic analysis; R.L.G. completed RNA analysis; S.H.R. provided primary HAE cultures; A.L. and W.A.M. provided critical monoclonal antibody reagents; and Z.-L.S. provided SHC014 spike sequences and plasmids. R.S.B. designed experiments and wrote manuscript.